Nicolas Cage is Charlie Kaufman, a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald (Nicolas Cage). While struggling to adapt "The Orchid Thief," by Susan Orlean (Meryl Streep), Kaufman's life spins from pathetic to bizarre. The lives of Kaufman, Orlean's book, become strangely intertwined as each one's search for passion collides with the others'.

Certain that the anonymous threats he's been receiving are the work of David Kahane (Vincent D'Onofrio), producer Griffin Mill (Tim Robbins) tries to fix things over cocktails. Instead, Griffin ends up murdering the screenwriter and courting the dead man's girlfriend (Greta Scacchi). As police investigate, Griffin concentrates on a prestigious film that might reinvigorate his career. But he soon learns that David's demise hasn't been forgotten by everyone in Hollywood.

A philistine in the art film business, Jeremy Prokosch (Jack Palance) is a producer unhappy with the work of his director. Prokosch has hired Fritz Lang (as himself) to direct an adaptation of "The Odyssey," but when it seems that the legendary filmmaker is making a picture destined to bomb at the box office, he brings in a screenwriter (Michel Piccoli) to energize the script. The professional intersects with the personal when a rift develops between the writer and his wife (Brigitte Bardot).